Protective effect of KIR3DS1 in asymptomatic HIV-1 seroconverters towards AIDS
نویسندگان
چکیده
Background The extreme variability at the Killer cell Immunoglobulin like Receptor (KIR) expressed on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA) Class I appear to play a crucial role in the outcome against viral infection. The combination of HLA/KIR gene products either individually or collectively have been implicated in the control of HIV-1 in various populations. Objective of this immunogenetic case-control study is to determine the association between KIR3DS1 and HIV-1 asymptomatism.
منابع مشابه
Time to Seroconversion in HIV-Exposed Subjects Carrying Protective versus Non Protective KIR3DS1/L1 and HLA-B Genotypes
Natural killer (NK) cells play a role in the clearance of viral infections. Combinations of alleles at the polymorphic HLA-B locus and the NK cell surface killer immunoglobulin-like receptor locus KIR3DL1/S1 have been shown to influence time to AIDS in HIV-infected individuals and risk of seroconversion in HIV exposed seronegative (HESN) subjects. Here, we assessed time to seroconversion or dur...
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